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KMID : 1036920120170030160
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Annals of Pediatric Endocrinology & Metabolism
2012 Volume.17 No. 3 p.160 ~ p.168
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Changes in the Predicted Adult Height after Gonadotropin-Releasing Hormone Agonist Treatment in Girls with Idiopathic True Precocious Puberty
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Kwon Eun-Byul
Lee Seung-Joon
Cha Min-Ah
Kim Se-Young
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Abstract
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Purpose: We evaluated the effects of the timing of treatment initiation with gonadotropin-releasing hormone agonist (GnRHa) on the change in predicted adult height (PAH) in girls with idiopathic true precocious puberty (TPP).
Methods: Data for this retrospective study were collected on 104 girls with TPP who were treated with GnRHa for 36 months, between January 2002 and March 2012.
Results: The PAH SDS differed before and after treatment in all patients (-1.91 ± 1.47 vs. -1.37 ± 1.17 after 1 year of treatment, -1.96 ± 1.58 vs. -0.48 ± 1.11 after 3 years of treatment) as well as in Group 1 (-2.15 ± 1.54 vs. -1.51 ± 1.20 after 1 year of treatment, -2.09 ± 1.59 vs. -0.55 ± 1.19 after 3 years of treatment) and Group 2 (-1.57 ± 1.34 vs. -1.17 ± 1.12 after 1 year of treatment, -1.50 ± 1.55 vs. -0.21 ± 0.74 after 3 years of treatment). This result could be due to improvement in bone age advancement during the treatment. The difference between mid-parental height SDS and PAH SDS was decreased after GnRHa treatment. However, the means of PAH SDS did not surpass the mid-parental height SDS.
Conclusion: GnRHa treatment can preserve growth potential by slowing bone age progression, resulting in short adult height, but it cannot alter the genetic growth potential.
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KEYWORD
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Puberty, precocious, Gonadotropin-releasing hormone, height
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